Two distinct periods of rapid molecular and microbial change occur around ages 44 and 60 in adults.
About 81% of the 135,000 + molecules and microbes studied exhibit non-linear fluctuations in abundance over time.
Mid-40s shifts affect molecules linked to alcohol, caffeine and lipid metabolism, cardiovascular health, skin and muscle.
Early 60s shifts impact carbohydrate and caffeine metabolism, immune regulation, kidney function, cardiovascular health, skin and muscle.
Both men and women experience the mid-40s biomolecular changes, indicating factors beyond menopause drive these shifts.
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