Vitamin C increases epidermal thickness by promoting keratinocyte proliferation in a human skin equivalent model.
Vitamin C treatment raises global 5-hydroxymethylcytosine levels by enhancing TET-mediated DNA demethylation.
Inhibition of TET enzymes blocks Vitamin C’s effects on DNA demethylation and epidermal cell proliferation.
Whole-genome bisulfite sequencing revealed over 10,000 hypomethylated regions and 4,808 affected genes under Vitamin C treatment.
Integrated methylome and transcriptome analysis identified 81 genes both hypomethylated and upregulated, including 12 key proliferation-related genes.
Vitamin C’s epigenetic regulation of proliferation-related genes suggests a promising approach to treat epidermal thinning and skin aging.
Vitamin C did not alter differentiation marker gene expression, indicating its primary action is on cell proliferation.
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