Vitamin C increases epidermal thickness and promotes keratinocyte proliferation in a human 3D epidermal model.
Vitamin C acts as a cofactor for TET DNA demethylation enzymes, raising global 5-hydroxymethylcytosine levels.
Inhibition of TET enzymes blocks vitamin C–induced DNA demethylation and keratinocyte proliferation.
Whole-genome bisulfite sequencing and microarray analysis identified hypomethylation and upregulation of 12 proliferation-related genes.
Vitamin C may serve as a therapeutic agent for epidermal thinning in aging by modulating DNA methylation.
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