AlphaGenome is a new AI model that predicts how single DNA variants impact gene regulation.
It processes very long DNA sequences (up to one million base-pairs) at single-base resolution.
The model predicts multiple molecular properties, including gene expression, splicing, and chromatin accessibility.
Variant effects are scored by comparing predictions for mutated versus unmutated sequences in one second.
AlphaGenome achieves state-of-the-art performance across diverse genomic prediction benchmarks.
It is available via a preview API for non-commercial research use.
Applications include disease mechanism studies, synthetic biology design, and fundamental genomic research.
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